Chinese Physics C > 2005, Vol. 29 > Issue(12): 1210-1213

Measurements of 41Ca in Biological Samples by AMS Using CaF2 Target

Department of Nuclear Physics,Chinese Institute of Atomic Energy,Beijing 102413,China

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Abstract：
For determining numbers of ⁴¹Ca labeled biological samples, the analytical method of ⁴¹Ca/ ⁴⁰Ca by Accelerator Mass Spectrometry (AMS) using CaF ₂target was developed at the Beijing HI-13 AMS system. ⁴¹Ca in the biological samples and ⁴¹Ca standard samples were prepared to CaF ₂with a more effective chemical separation and purification procedure. In the ⁴¹Ca AMS measurement, CaF ₃ ^－negative ion was extracted from ion resource, 7 ⁺charge state of particles was chosen after carbon foil stripping and accelerated at 8.5MV terminal voltage. ⁴¹Ca ions were finally recorded by an 140mbar P10 gas filled multi-anode ionization chamber detector. The results showed that ⁴¹Ca and the main isobar, ⁴¹K could be clearly identified in the two-dimensional density spectra, and the interference of ⁴¹K to ⁴¹Ca was eliminated with the very low ⁴¹K counting rate. The absolute measured values of 4 standard samples with ⁴¹Ca/ ⁴⁰Ca in the range of 1.785×10 ^－8—1.750×10 ^－10were in good linear relationship with the standard values (r ²=0.997). After normalized with the 1.785×10 ^－8 ⁴¹Ca/ ⁴⁰Ca standard, the measured values of S2 and S4 standard samples were in good agreement with the nominal values, however, the measured value of S3 deviated the nominal value largely. The ⁴¹Ca/ ⁴⁰Ca of the biological blanks were estimated below 8.2×10 ^－13.

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LI Shi-Hong, JIANG Shan, HE Ming, GUAN Yong-Jing, DONG Ke-Jun, WU Shao-Yong, YUAN Yuan, MI Sheng-Quan, LIU Shu-Tian and YUAN Jian. Measurements of 41Ca in Biological Samples by AMS Using CaF2 Target[J]. Chinese Physics C, 2005, 29(12): 1210-1213.

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Received: 2005-03-04
Revised: 1900-01-01

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沈阳化工大学材料科学与工程学院沈阳 110142

Measurements of 41Ca in Biological Samples by AMS Using CaF2 Target

Corresponding author:LI Shi-Hong,

Department of Nuclear Physics,Chinese Institute of Atomic Energy,Beijing 102413,China

Received Date:2005-03-04
Accepted Date:1900-01-01
Available Online:2005-12-05

Abstract:For determining numbers of⁴¹Ca labeled biological samples, the analytical method of⁴¹Ca/⁴⁰Ca by Accelerator Mass Spectrometry (AMS) using CaF₂target was developed at the Beijing HI-13 AMS system.⁴¹Ca in the biological samples and⁴¹Ca standard samples were prepared to CaF₂with a more effective chemical separation and purification procedure. In the⁴¹Ca AMS measurement, CaF₃^－negative ion was extracted from ion resource, 7⁺charge state of particles was chosen after carbon foil stripping and accelerated at 8.5MV terminal voltage.⁴¹Ca ions were finally recorded by an 140mbar P10 gas filled multi-anode ionization chamber detector. The results showed that⁴¹Ca and the main isobar,⁴¹K could be clearly identified in the two-dimensional density spectra, and the interference of⁴¹K to⁴¹Ca was eliminated with the very low⁴¹K counting rate. The absolute measured values of 4 standard samples with⁴¹Ca/⁴⁰Ca in the range of 1.785×10^－8—1.750×10^－10were in good linear relationship with the standard values (r²=0.997). After normalized with the 1.785×10^－8⁴¹Ca/⁴⁰Ca standard, the measured values of S2 and S4 standard samples were in good agreement with the nominal values, however, the measured value of S3 deviated the nominal value largely. The⁴¹Ca/⁴⁰Ca of the biological blanks were estimated below 8.2×10^－13.