Chinese Physics C > 2015, Vol. 39 > Issue(3): 038001 DOI: 10.1088/1674-1137/39/3/038001

Small-angle X-ray scattering probe of intermolecularinteraction in red blood cells

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Abstract：
With high concentrations of hemoglobin (Hb) in red blood cells, self-interactions among these molecules could increase the propensities of their polymerization and aggregation. In the present work, high concentration Hb in solution and red blood cells were analyzed by small-angle X-ray scattering. Calculation of the effective structure factor indicates that the interaction of Hb molecules is the same when they are crowded together in both the cell and physiological saline. The Hb molecules stay individual without the formation of aggregates and clusters in cells.

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LIU Guan-Fen, WANG We-Jia, XU Jia-Hua and DONG Yu-Hui. Small-angle X-ray scattering probe of intermolecularinteraction in red blood cells[J]. Chinese Physics C, 2015, 39(3): 038001. doi: 10.1088/1674-1137/39/3/038001

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Received: 2014-04-07
Revised: 2014-08-12

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沈阳化工大学材料科学与工程学院沈阳 110142

Small-angle X-ray scattering probe of intermolecularinteraction in red blood cells

Corresponding author:DONG Yu-Hui,

Received Date:2014-04-07
Accepted Date:2014-08-12
Available Online:2015-03-05

Abstract:With high concentrations of hemoglobin (Hb) in red blood cells, self-interactions among these molecules could increase the propensities of their polymerization and aggregation. In the present work, high concentration Hb in solution and red blood cells were analyzed by small-angle X-ray scattering. Calculation of the effective structure factor indicates that the interaction of Hb molecules is the same when they are crowded together in both the cell and physiological saline. The Hb molecules stay individual without the formation of aggregates and clusters in cells.