Chinese Physics C > 2005, Vol. 29 > Issue(S1): 76-79

Translocation of Inhaled TiO2 Nanoparticles Along Olfactory Nervous System to Brain Studied by Synchrotron Radiation X-Ray Fluorescence

Institute of High Energy Physics, CAS,Beijing 100049,China2 Graduate School of the CAS,Beijing 100049,China

Abstract
HTML
Reference
Related

PDF

Abstract：
Nanosized TiO ₂is widely used for cleaning air,antibacterial and decomposing organic in wastewater for its highly photocatalytic function. TiO ₂inhalation via respiratory tracts is the most common route of its exposure in industry and environment. After inhalation by human or rodents, TiO ₂can induce inflammation and pulmonary lesions, which was reported to even cause lung cancer by long-term exposure. In this paper, Synchrotron Radiation X-ray Fluorescence was employed to investigate the distribution of TiO ₂in the olfactory bulb and brain of mice after inhalation of TiO ₂particles suspension.The results showed that TiO ₂could enter the olfactory nerve layer (ON), granular cell layer of olfactory bulb (Gro), and olfactory ventricle (OV) and further the hippocampus, thalamus,and CA3 area of the brain through the olfactory nervous system.The distribution area of microsized TiO ₂was wider than that of nanosized TiO ₂.

References

[1]

. Ferin J, Oberd#246;rster G, Penny D P. Am. J. Respir Cell Mol Biol, 1992, 6: 5352. Donaldson K, LI X Y, MacNee W. J. Aerosol Sci., 1998,29(5): 5533. Oberd#246;rster G, Ferin J, Lehnert B E. Environ Health Perspect,1994, 102(Supp.5): 173—1794. ZHANG Q W, Kusaka Y, Donaldson K. Inhal Toxicol,2000, 12(Supp.3): 2675. Oberd#246;rster G, Sharp Z, Atudorei V et al. Inhal Toxicol,2004, 16(6-7): 4376. ZHANG Zhi-Yong, LIU Nian-Qing, LI Fu-Liang et al. HEP NP, 2003, 27(Supp.): 114(in Chinese)(张智勇，刘年庆，李福亮等.高能物理与核物理，2003, 27(增刊):114)7. ZHANG Yu-Zhi. Studies of Trace Elements and Health,2004, 21(3): 56(in Chinese)(张玉芝.微量元索与健康研究，2004, 21(3): 56)8. HUANG Yan-E. Hebei Journal of Industrial Science Technology, 2001, 18(2): 7(in Chinese)(黄艳娥.河北工业科技，2001,18(2):7)9. Oberd#246;rster G. Phil Trans R Soc Lond A, 2000, 358: 2719

[1]	ZHAO Tian-Xing,FENG Ya-Juan,HUANG Jun-Heng,HE Jin-Fu,LIU Qing-Hua,PAN Zhi-Yun,WU Zi-Yu. Local structure and optical absorption characteristic investigationon Fe doped TiO₂nanoparticles. Chinese Physics C, 2015, 39(2): 028001.doi:10.1088/1674-1137/39/2/028001
[2]	CHEN Dong-Liang,WU Zi-Yu,WEI Shi-Qiang. MS-XANES Studies on the Interface Effect of Semiconductor InSb Nanoparticles Embedded in a-SiO₂Matrix. Chinese Physics C, 2006, 30(5): 476-480.
[3]	HAO Hu-Lin,FENG Ying,HUANG Yu-Ying,TIAN Sheng-Ke,LU Ling-Li,YANG Xiao-E,WEI You-Zhang. In Situ Analysis of Cellular Distribution of Iron and Zinc in Rice Grain Using SRXRF Method. Chinese Physics C, 2005, 29(S1): 56-60.
[4]	WANG Bing,FENG Wei-Yue,WANG Meng,SHI Jun-Wen,ZHANG Fang,OUYANG Hong,ZHAO Yu-Liang,CHAI Zhi-Fang,HUANG Yu-Ying,XIE Ya-Ning. Microtranslocation of Trace Element in the Olfactory Bulb of Mice after Intranasal Instillation of Fine Oxide Particle by Synchrotron Radiation X-Ray Fluorescence. Chinese Physics C, 2005, 29(S1): 71-75.
[5]	LIU Miao,QI Ze-Ming,SHI Chao-Shu,XU Mei,ZHANG Wei-Ping,LIU Tao,XIE Ya-Ning. EXAFS Study the Local Structure of Nanocrystalline Lu₂O₃:Eu. Chinese Physics C, 2005, 29(S1): 93-96.
[6]	ZHANG Yuan-Xun,WANG Ying-Song,LI De-Lu,ZHANG Gui-Lin,HUANG Yu-Ying,HE Wei,LONG Jian-Gang,SHEN Hui. Zinc and ZnT3 mRNA Expression in Mouse Brain by SRXRF. Chinese Physics C, 2005, 29(S1): 68-70.
[7]	XU Yan-Bing. Influence of 1h_11/2Orbit on the Shapes of Even Even Nuclei Around A～100 Region. Chinese Physics C, 2004, 28(6): 601-606.
[8]	ZHAO Xiu-Mei,CAO Li-Ke,YANG Tao,YUE Rui-Hong. Integrability of a Quantum Derivative Nonlinear Schrodinger Model for Spin-1/2 Particle. Chinese Physics C, 2004, 28(9): 936-940.
[9]	CHENG Lin,FENG Song-Lin,XU Qing,HUANG Yu-Ying,HE Wei,LV Zhi-Rong. Colored Glaze from Shanxi Province Studied by SRXRF and Multivariable Statistical Analysis. Chinese Physics C, 2003, 27(S1): 97-100.
[10]	FENG Song-Lin,XU Qing,LEI Yong,CHENG Lin,FENG Xiang-Qian,FAN Dong-Yu,SHA Yin,HUANG Yu-Ying,HE Wei. Study of Minimum Analytic Mass of Microanalysis reference Material with SRXRF. Chinese Physics C, 2003, 27(S1): 105-108.
[11]	XIAO Wan-Sheng,WENG Ke-Nan,XU Shi-Ping,CHEN Jin-Yang,HONG Shi-Ming,HAN Yin-Wen. Study on elemental mobility in the process of ultrahigh-pressure metamorphism by SRXRF. Chinese Physics C, 2003, 27(S1): 77-82.
[12]	HONG Xin-Guo,DU Lu-Chao,YE Man-Ping,WENG Yu-Xiang,LI Ming. In Situ Synchrotron Small Angle X-ray Scattering Studies of TiO₂Colloid at Elevated Temperature. Chinese Physics C, 2003, 27(S1): 63-66.
[13]	CUI Shu-Fan,LUO Guang-Ming,YU Wen-Xue,CHEN Xiang-Ming,LIU Cui-Xiu,LI Ming,MAI Zhen-Hong,LU Hui-Bin,CHEN Zheng-Hao,JIA Quan-Jie,ZHENG Wen-Li,JIANG Xiao-Ming. Bragg Diffraction and Its Simulation of Ba TiO₃/SrTiO₃Superlattices. Chinese Physics C, 2001, 25(S1): 100-105.
[14]	WANG Zhen-Xia,WANG Wen-Min,RUAN Mei-Ling. Formation of Boron Nitride Nanostructures by Means of 60keV N2+ Ion Beam Bombardment. Chinese Physics C, 2001, 25(2): 174-178.
[15]	FAN Dong-Yu,FENG Song-Lin,XU Qing,ZHANG Ying,FENG Xiang-Qian,LEI Yong,CHENG Lin,SHA Yin,CHAI Zhi-Fang,HUANG Yu-Ying,HE Wei,QUAN Kui-Shan,SHEN Yue-Ming. Study of Elements in Yue Kiln Ancient Porcelain by SRXRF. Chinese Physics C, 2001, 25(S1): 49-53.
[16]	Ma Yinqun,Zhuang Youxiang,Zhang Zhengjun. Systematics Research on (p, n) and (p,2n) Reaction Excitation Functions. Chinese Physics C, 1998, 22(3): 271-276.
[17]	LI Fu-Bin. Description of the Complete Integrability of the SU(2) and SU(3) Self-Dual Yang-Mills Source-Free Field Equations System and Further Discussions. Chinese Physics C, 1992, 16(5): 408-413.
[18]	YAO Li-Shan,CAI Dun-Jiu. A SYSTEMATIC STUDY OF EXCITATION FUNCTIONS FOR (n,2n) AND (n,3n) REACTIONS. Chinese Physics C, 1990, 14(3): 266-270.
[19]	YAO Li-Shan,ZHOU En-Chen,CAI Dun-Jiu. A SYSTEMATIC STUDY OF (n, 2n) CROSS SECTION AT 14MeV. Chinese Physics C, 1987, 11(4): 533-542.
[20]	SONG Xiao-Tong,CHING Cheng-Rui,HO Tso-Hsiu. APPROXIMATE B.S. WAVE FUNCTIONS FOR AN ELECTROMAGNETIC BOUND SYSTEM OF SPINS (1/2, 1/2) OR (1/2, 1/2) WITH UNEQUAL MASSES. Chinese Physics C, 1984, 8(5): 531-538.

Access

Get Citation

WANG Jiang-Xue, CHEN Chun-Ying, SUN Jin, YU Hong-Wei, LI Yu-Feng, LI Bai, XING Li, HUANG Yu-Ying, HE Wei, GAO Yu-Xi, CHAI Zhi-Fang and ZHAO Yu-Liang. Translocation of Inhaled TiO2 Nanoparticles Along Olfactory Nervous System to Brain Studied by Synchrotron Radiation X-Ray Fluorescence[J]. Chinese Physics C, 2005, 29(S1): 76-79.

RIS(for EndNote,Reference Manager,ProCite)

BibTex

Txt

Milestone

Received: 2005-10-28
Revised: 1900-01-01

Article Metric

Article Views(5710)
PDF Downloads(701)
Cited by(0)

Policy on re-use

To reuse of subscription content published by CPC, the users need to request permission from CPC, unless the content was published under an Open Access license which automatically permits that type of reuse.

通讯作者:陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Translocation of Inhaled TiO2 Nanoparticles Along Olfactory Nervous System to Brain Studied by Synchrotron Radiation X-Ray Fluorescence

Corresponding author:CHEN Chun-Ying,

Institute of High Energy Physics, CAS,Beijing 100049,China2 Graduate School of the CAS,Beijing 100049,China

Received Date:2005-10-28

Accepted Date:1900-01-01

Available Online:2005-01-02

Abstract:Nanosized TiO₂is widely used for cleaning air,antibacterial and decomposing organic in wastewater for its highly photocatalytic function. TiO₂inhalation via respiratory tracts is the most common route of its exposure in industry and environment. After inhalation by human or rodents, TiO₂can induce inflammation and pulmonary lesions, which was reported to even cause lung cancer by long-term exposure. In this paper, Synchrotron Radiation X-ray Fluorescence was employed to investigate the distribution of TiO₂in the olfactory bulb and brain of mice after inhalation of TiO₂particles suspension.The results showed that TiO₂could enter the olfactory nerve layer (ON), granular cell layer of olfactory bulb (Gro), and olfactory ventricle (OV) and further the hippocampus, thalamus,and CA3 area of the brain through the olfactory nervous system.The distribution area of microsized TiO₂was wider than that of nanosized TiO₂.

HTML

Reference (1)

Translocation of Inhaled TiO2 Nanoparticles Along Olfactory Nervous System to Brain Studied by Synchrotron Radiation X-Ray Fluorescence

Abstract：

References

Access

Article Metrics

Metrics

通讯作者:陈斌, bchen63@163.com

Email This Article