\begin{document}$ \rm fb^{-1} $\end{document}, the process \begin{document}$ e^+e^- \to p p \bar{p} \bar{n} \pi^{-} + c.c. $\end{document} is observed for the first time with a statistical significance of \begin{document}$ 11.5\sigma $\end{document}. The average Born cross sections in the energy ranges of (4.160, 4.380) GeV, (4.400, 4.600) GeV and (4.610, 4.700) GeV are measured to be \begin{document}$ (21.5\pm5.7\pm1.2) $\end{document} fb, \begin{document}$ (46.3\pm10.6\pm2.5) $\end{document} fb and \begin{document}$ (59.0\pm9.4\pm3.2) $\end{document} fb, respectively, where the first uncertainties are statistical and the second are systematic. The line shapes of the \begin{document}$ \bar{p}\bar{n} $\end{document} and \begin{document}$ pp\pi^- $\end{document} invariant mass spectra are consistent with phase space distributions, indicating that no hexaquark or di-baryon state is observed."> Observation of <inline-formula><tex-math id="M1">\begin{document}${ {\boldsymbol e^+\boldsymbol e^- \to\boldsymbol p\boldsymbol p \bar{\boldsymbol p} \bar{\boldsymbol n} \boldsymbol\pi^{-} + \boldsymbol c.\boldsymbol c. }}$\end{document}</tex-math><alternatives><graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="//www.macurncorp.com/hepnp/article/app/id/5cd9a3a2-971b-493e-8f3d-71dd71f09cae/CPC-2022-0567_M1.jpg"/><graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="//www.macurncorp.com/hepnp/article/app/id/5cd9a3a2-971b-493e-8f3d-71dd71f09cae/CPC-2022-0567_M1.png"/></alternatives></inline-formula> -
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