\begin{document}$ N=20,28,50 $\end{document} shell closures in the \begin{document}$ 20 \leqslant Z \leqslant 30 $\end{document} region. We show how these three conventional shell closures evolve from the proton drip line to the neutron drip line by studying the charge radii, two-neutron separation energies, two-neutron gaps, quadrupole deformations, and single-particle levels. In particular, we find that in the \begin{document}$ 21 \leqslant Z \leqslant 27 $\end{document} region, the \begin{document}$ N=50 $\end{document} shell closure disappears or becomes quenched, mainly due to the deformation effects. Similarly, both experimental data and theoretical predictions indicate that the \begin{document}$ N=28 $\end{document} shell closure disappears in the Mn isotopic chain, mainly due to the deformation effects. The DRHBc theory predicts the existence of the \begin{document}$ N=20 $\end{document} shell closure in the Ca, Sc, and Ti isotopic chains, but the existing data for the Ti isotopes suggest the contrary, and therefore further research is needed."> Evolution of <i>N</i> = 20, 28, 50 shell closures in the 20 ≤ <i>Z</i> ≤ 30 region in deformed relativistic Hartree-Bogoliubov theory in continuum -
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